谢玉生，教授/博导，药理系副主任/党支部副书记。香港城市大学/新加坡国立大学博士，香港城市大学/德国马克斯普朗克分子生理学研究所博士后。主要从事蛋白质邻近标记工具的开发与应用，致力于构建“工具创制−机制发现−药物干预”的研究范式，重点聚焦于脂滴蛋白标记与共价靶向药物开发。研究工作发表在JACS、Angew、Trends Anal. Chem.、Anal. Chem.等领域权威期刊。获得国家自然科学基金青年/面上项目、山东省泰山学者青年专家/优秀青年科学基金（海外）、山东大学齐鲁青年学者等科研基金的资助。
E-mail: yushengxie@sdu.edu.cn.
Group Website: https://www.x-mol.com/groups/xie_yusheng；
https://faculty.sdu.edu.cn/xieyusheng/zh_CN/index.htm.
代表性工作
1) Jing Xiang,‡ Hao Wang,‡ Longhui Li,‡ Xuelin Yang,‡ Guangyu Xu, Jiaqian Yan, Tao Li, Zhengyang Shi, Chunfa Xu, Rui Wang,* Qidong Tu,* Miaomiao Wang,* and Yusheng Xie.* Activity-Based Multimodal Probes Uncover the AChE-ADGRB Axis in Cellular and Murine Models of Depression. Anal. Chem. 2026, 98, 4, 3040–3050.
2) Jing Xiang,‡ Tao Li,‡ Junzhe Zhang,‡ Wenxian Wu,‡ Guangyu Xu, Jiaqian Yan, Hao Wang, Suyuan Chen, Shao Q. Yao, Miaomiao Wang,* Fan Yi,* Jigang Wang,* Yusheng Xie.* Chemical Probe-Enabled Lipid Droplet Proteomics. J. Am. Chem. Soc. 2025, 147, 12, 10724–10736.
3) Tao Li,‡ Wenjie Zhang,‡ Yiqing Wang,‡ Guangyu Xu,‡ Fengfei Miao, Peng Chen, Guanghui Tang, Xiaotong Ze, Jing Xiang, Jiaqian Yan, Miaomiao Wang, Min Liu, Xiaojie Wang, Wei Tang, Fan Yi, Zhi-Min Zhang,* Rui Wang,* Shao Q Yao,* Yusheng Xie* Lysine-targeting, Covalent Inhibitors of Bromodomain BD1 of BET Proteins in Live Cells and Animals. Angew. Chem. Int. Ed., 2025, e202424832.
4) Yaochen Tu, ‡ Wenjie Zhang, ‡ Jiaqian Yan, Miaomiao Wang, Bubin Xu,* Yusheng Xie.* Trends in small-molecule probes for lipid droplets. Trends Anal. Chem. 2025, 190, 118287.
5) Hui, C.; Wang, Z.; Xie, Y.;* Liu, J.* Contemporary synthesis of bioactive cyclobutane natural products. Green Synthesis and Catalysis. 2023, 4, 1-6.
6) Xie, Y.; ‡ Shubo Du; ‡ Zhiyang Liu; Min Liu; Zhiqiang Xu; Xiaojie Wang; Jia Xuan Kee; Fan Yi;* Hongyan Sun;* Shao Q. Yao* Chemical biology tools for protein lysine acylation. Angew. Chem., Int. Ed. 2022, 61, e202200303.
7) Xie, Y.;† Yang, L.;† Chen, Q.; Zhang, J.; Feng, L.; Chen, J. L.; Hao, Q.; Zhang, L.; Sun, H.* Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions. Eur. J. Med. Chem. 2021, 212, 113120.
8) Feng, L.;† Xie, Y.;†* Au-Yeung, S. K.; Hailu, H. B.; Liu, Z.; Chen, Q.; Zhang, J.; Pang, Q.; Yao, X.; Yang, M.; Zhang, L.;* Sun, H.* A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells. Chem. Commun. 2020, 56 (60), 8480-8483.
9) Xie, Y.;‡ Chen, L.;‡ Wang, R.;‡ Wang, J.; Li, J.; Xu, W.; Li, Y.; Yao, S. Q.; Zhang, L.;* Hao, Q.;* Sun, H.* Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation. J. Am. Chem. Soc. 2019, 141 (46), 18428-18436.
10) Xie, Y.; Ge, J.; Lei, H.; Peng, B.; Zhang, H.; Wang, D.; Pan, S.; Chen, G.; Chen, L.; Wang, Y.; Hao, Q.; Yao, S. Q.; Sun, H.* Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. J. Am. Chem. Soc. 2016, 138 (48), 15596-15604.
